As a DHT derivative, oxandrolone does not aromatize (convert to estrogen, which causes gynecomastia or male breast tissue). It also does not significantly influence the body's normal testosterone production at low dosages (10 mg). When dosages are high, the human body reacts by reducing the production of LH (luteinizing hormone), thinking endogenous testosterone production is too high, this in turn eliminates further stimulation of Leydig cells in the testicles, causing testicular atrophy (shrinking). Oxandrolone used in a dose of 80 mg/day suppressed endogenous testosterone by 67% after 12 weeks of therapy. 50 x 10mg tablets